CIDOC CRM as the basis of the Electronic State Register of Immovable Cultural Heritage of Ukraine

Abstract. The article is the final in a series of articles on Conceptual Provisions for the Creation of a New Electronic State Register of Immovable Cultural Heritage (CH) of Ukraine. These provisions correspond to the components of the Solutions Framework (SoFr) of special Spatial Information Systems (SpIS) defined in the monograph [15]. The special SpIS of the new registry of the CH of Ukraine should belong to the class of Atlas Geoinformation Systems (AGIS), which is described in [14]. The first queue of AGIS – AGIS-CH1 – is proposed as the first queue of the new electronic State Register of Immovable CH of Ukraine. The first queue should include, at least, three components that are simultaneously SoFr packages: Products-Processes-Basics. The conceptual provisions of AGIS-CH1 describe these three most important components of the architectural pattern of AGIS-CH1: AGIS-CH1.Products, Part 1 [17]; AGIS-CH1.Processes, Part 2 [18], AGIS-CH1.Basics, Part 3, consisting of two subparts, 3.1 and 3.2. Subpart 3.1 is described in the article [19]. This article describes subpart 3.2, which is called "Basics. CIDOC CRM". It consists of two main sections. The first of these initially examines the prerequisites that lead to the use of CIDOC CRM. Such prerequisites are two evolutions: system and subject. System evolution claims that the time has come to consider the registry of the CH of Ukraine as a SpIS of the Web 3.0 Formation, also known as the Semantic Web, especially if we have in mind the creation of a new registry. Subject evolution refers to the evolution of understanding of the domain of cultural heritage. From the review of this issue in the monograph [4], it is obvious that modern CH registers should be "process" rather than "product". In order to proceed to the consideration of CIDOC CRM with a better understanding of the essence of the issue, the CHARM model (Cultural Heritage Abstract Reference Model) was considered. CIDOC CRM can also be considered as such, but CHARM is described in an excellent monograph [4] that is practically applicable, unlike the scattered articles on CIDOC CRM. The second of the two main sections of the article deals with CIDOC CRM and its use. We do not describe CIDOC CRM completely. Attention is paid only to its "spatial" and "process" parts. In addition, attention is paid to the use of CIDOC CRM. For this, the information from the website (https://www.cidoc-crm.org/how-i-can-use-cidoc-crm, 2023-jun-26) is used first. Then there is some initial information about the Arches software platform. We offer the Arches platform for the implementation of AGIS-CH1. Key words: Solutions Framework (SoFr), Atlas geoinformation system (AGIS), Basics of AGIS SoFr, register of CH as the first queue of AGIS

Coulomb and Spin blockade of two few-electrons quantum dots in series in the co-tunneling regime

We present Coulomb Blockade measurements of two few-electron quantum dots in series which are configured such that the electrochemical potential of one of the two dots is aligned with spin-selective leads. The charge transfer through the system requires co-tunneling through the second dot which is $not$ in resonance with the leads. The observed amplitude modulation of the resulting current is found to reflect spin blockade events occurring through either of the two dots. We also confirm that charge redistribution events occurring in the off-resonance dot are detected indirectly via changes in the electrochemical potential of the aligned dot.Comment: 6 pages, 5 figures, submitted to Phys. Rev.

Charge Sensing of an Artificial H2+ Molecule

We report charge detection studies of a lateral double quantum dot with controllable charge states and tunable tunnel coupling. Using an integrated electrometer, we characterize the equilibrium state of a single electron trapped in the doubled-dot (artificial H2+ molecule) by measuring the average occupation of one dot. We present a model where the electrostatic coupling between the molecule and the sensor is taken into account explicitly. From the measurements, we extract the temperature of the isolated electron and the tunnel coupling energy. It is found that this coupling can be tuned between 0 and 60 micro electron-volt in our device.Comment: 5 pages, 4 figures. Revised version with added material. To be published in Physical Review

Main conceptual provisions of the creation of an electronic state register of immovable cultural heritage of Ukraine. Part 1

Annotation. To organize the creation of a new modern electronic State Register of Immovable Cultural Heritage (CH) of Ukraine, it is proposed to use a methodology based on the so-called Solutions Frameworks (SoFr) "something" = X, where X denotes both the specified system (subsystem) and class of such systems (subsystems). The application of SoFr to X entirely is called the main conceptual position 0 in the article, but despite its obviousness, the epigraph is applicable to the construction of X SoFr: “The hardest thing is to see what is right in front of you. - Goethe» [1; Preface]. X in the X SoFr record takes the meaning of a hierarchically structured Atlas Geoinformation System (AGIS), consisting of four strata (bottom-up ­): Operational (w), Application (a), Conceptual (b) and General (g). X SoFr in the article takes three meanings: SoFr AGIS1 (defines the activity of creating the first stage of AGIS - AGIS1 = X), aSoFr AGIS1 (defines the activity "between" subsystems AGIS1 Application and Operational strata top-down ¯), bSoFr AGIS1 determines the activity "between" the subsystems of AGIS1 Conceptual and Application strata from top to bottom ¯).  X SoFr is determined by the packages and the relation between them, the so-called "petrad" of Publication-Products-Processes-Basics-Services. Packages Products-Processes-Basics and the relation between them are called the main triad of SoFr. This triad is the basis of the main conceptual provisions 1-3. They are formulated as follows: SoFr.Products - provision 1, SoFr.Processes - provision 2, SoFr.Basics - provision 3. Part 1 describes the introduction to the problem and provisions 0 and 1. Provisions 2, 3 are described in Part 2. The methodology, based on the Solutions Frameworks, implements a specific systematic approach to creating a new modern electronic State Register of Immovable Cultural Heritage of Ukraine

Voltage-tunable singlet-triplet transition in lateral quantum dots

Results of calculations and high source-drain transport measurements are presented which demonstrate voltage-tunable entanglement of electron pairs in lateral quantum dots. At a fixed magnetic field, the application of a judiciously-chosen gate voltage alters the ground-state of an electron pair from an entagled spin singlet to a spin triplet.Comment: 8.2 double-column pages, 10 eps figure

Large tunable valley splitting in edge-free graphene quantum dots on boron nitride

Coherent manipulation of binary degrees of freedom is at the heart of modern quantum technologies. Graphene offers two binary degrees: the electron spin and the valley. Efficient spin control has been demonstrated in many solid state systems, while exploitation of the valley has only recently been started, yet without control on the single electron level. Here, we show that van-der Waals stacking of graphene onto hexagonal boron nitride offers a natural platform for valley control. We use a graphene quantum dot induced by the tip of a scanning tunneling microscope and demonstrate valley splitting that is tunable from -5 to +10 meV (including valley inversion) by sub-10-nm displacements of the quantum dot position. This boosts the range of controlled valley splitting by about one order of magnitude. The tunable inversion of spin and valley states should enable coherent superposition of these degrees of freedom as a first step towards graphene-based qubits

A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis

The cause of sporadic amyotrophic lateral sclerosis (ALS) is largely unknown, but genetic factors are thought to play a significant role in determining susceptibility to motor neuron degeneration. To identify genetic variants altering risk of ALS, we undertook a two-stage genome-wide association study (GWAS): we followed our initial GWAS of 545 066 SNPs in 553 individuals with ALS and 2338 controls by testing the 7600 most associated SNPs from the first stage in three independent cohorts consisting of 2160 cases and 3008 controls. None of the SNPs selected for replication exceeded the Bonferroni threshold for significance. The two most significantly associated SNPs, rs2708909 and rs2708851 [odds ratio (OR) = 1.17 and 1.18, and P-values = 6.98 x 10–7 and 1.16 x 10–6], were located on chromosome 7p13.3 within a 175 kb linkage disequilibrium block containing the SUNC1, HUS1 and C7orf57 genes. These associations did not achieve genome-wide significance in the original cohort and failed to replicate in an additional independent cohort of 989 US cases and 327 controls (OR = 1.18 and 1.19, P-values = 0.08 and 0.06, respectively). Thus, we chose to cautiously interpret our data as hypothesis-generating requiring additional confirmation, especially as all previously reported loci for ALS have failed to replicate successfully. Indeed, the three loci (FGGY, ITPR2 and DPP6) identified in previous GWAS of sporadic ALS were not significantly associated with disease in our study. Our findings suggest that ALS is more genetically and clinically heterogeneous than previously recognized. Genotype data from our study have been made available online to facilitate such future endeavors

The Influence of Surface Roughness on Nucleate Pool Boiling Heat Transfer

The effect of surface roughness on pool boiling heat transfer is experimentally explored over a wide range of roughness values in water and Fluorinert™ FC-77, two fluids with different thermal properties and wetting characteristics. The test surfaces ranged from a polished surface (Ra between 0.027 micrometer and 0.038 micrometer) to electrical discharge machined (EDM) surfaces with a roughness Ra ranging from 1.08 micrometer to 10.0 micrometer. Different trends were observed in the heat transfer coefficient with respect to the surface roughness between the two fluids on the same set of surfaces. For FC-77, the heat transfer coefficient was found to continually increase with increasing roughness. For water, on the other hand, EDM surfaces of intermediate roughness displayed similar heat transfer coefficients that were higher than for the polished surface, while the roughest surface showed the highest heat transfer coefficients. The heat transfer coefficients were more strongly influenced by surface roughness with FC-77 than with water. For FC-77, the roughest surface produced 210% higher heat transfer coefficients than the polished surface while for water, a more modest 100% enhancement was measured between the same set of surfaces. Although the results highlight the inadequacy of characterizing nucleate pool boiling data using Ra, the observed effect of roughness was correlated using hRa m as has been done in several prior studies. The experimental results were compared with predictions from several widely used correlations in the literature

Attitudes towards fibromyalgia: A survey of Canadian chiropractic, naturopathic, physical therapy and occupational therapy students

<p>Abstract</p> <p>Background</p> <p>The frequent use of chiropractic, naturopathic, and physical and occupational therapy by patients with fibromyalgia has been emphasized repeatedly, but little is known about the attitudes of these therapists towards this challenging condition.</p> <p>Methods</p> <p>We administered a cross-sectional survey to 385 senior Canadian chiropractic, naturopathic, physical and occupational therapy students in their final year of studies, that inquired about attitudes towards the diagnosis and management of fibromyalgia.</p> <p>Results</p> <p>336 students completed the survey (response rate 87%). While they disagreed about the etiology (primarily psychological 28%, physiological 23%, psychological and physiological 15%, unsure 34%), the majority (58%) reported that fibromyalgia was difficult to manage. Respondants were also conflicted in whether treatment should prioritize symptom relief (65%) or functional gains (85%), with the majority (58%) wanting to do both. The majority of respondents (57%) agreed that there was effective treatment for fibromyalgia and that they possessed the required clinical skills to manage patients (55%).</p> <p>Chiropractic students were most skeptical in regards to fibromyalgia as a useful diagnostic entity, and most likely to endorse a psychological etiology. In our regression model, only training in naturopathic medicine (unstandardized regression coefficient = 0.33; 95% confidence interval = 0.11 to 0.56) and the belief that effective therapies existed (unstandardized regression coefficient = 0.42; 95% confidence interval = 0.30 to 0.54) were associated with greater confidence in managing patients with fibromyalgia.</p> <p>Conclusion</p> <p>The majority of senior Canadian chiropractic, naturopathic, physical and occupational therapy students, and in particular those with naturopathic training, believe that effective treatment for fibromyalgia exists and that they possess the clinical skillset to effectively manage this disorder. The majority place high priority on both symptom relief and functional gains when treating fibromyalgia.</p

Longitudinal Tracking of Human Fetal Cells Labeled with Super Paramagnetic Iron Oxide Nanoparticles in the Brain of Mice with Motor Neuron Disease

Stem Cell (SC) therapy is one of the most promising approaches for the treatment of Amyotrophic Lateral Sclerosis (ALS). Here we employed Super Paramagnetic Iron Oxide nanoparticles (SPIOn) and Hoechst 33258 to track human Amniotic Fluid Cells (hAFCs) after transplantation in the lateral ventricles of wobbler (a murine model of ALS) and healthy mice. By in vitro, in vivo and ex vivo approaches we found that: 1) the main physical parameters of SPIOn were maintained over time; 2) hAFCs efficiently internalized SPIOn into the cytoplasm while Hoechst 33258 labeled nuclei; 3) SPIOn internalization did not alter survival, cell cycle, proliferation, metabolism and phenotype of hAFCs; 4) after transplantation hAFCs rapidly spread to the whole ventricular system, but did not migrate into the brain parenchyma; 5) hAFCs survived for a long time in the ventricles of both wobbler and healthy mice; 6) the transplantation of double-labeled hAFCs did not influence mice survival